West Texas A&M (43-12) is the unanimous No. 1 in the final NFCA Division II Top 25 Coaches Poll. WTAMU won the programs second national title in 2021. The Lady Buffs received all 16 first-place votes.
| Rank | School | Points | 2021 Record | Last Poll |
| 1 | West Texas A&M (16) | 400 | 43-12 | 12 |
| 2 | Biola | 384 | 26-16 | 24 |
| 3 | Augustana | 366 | 49-8 | 1 |
| 4 | North Georgia | 354 | 43-8 | 2 |
| 5 | Grand Valley State | 328 | 45-10 | 13 |
| 6 | Valdosta State | 310 | 38-11 | 9 |
| 7 | Saint Anselm | 305 | 33-7 | 18 |
| 8 | West Chester University | 267 | 34-16 | |
| 9 | Texas A&M-Commerce | 263 | 33-18 | 10 |
| 10 | Lincoln Memorial | 259 | 38-8 | 5 |
| 11 | Indianapolis | 248 | 46-8 | 7 |
| 12 | Concordia Irvine | 206 | 34-13 | 11 |
| 13 | Minnesota State | 197 | 40-10 | 17 |
| 14 | Oklahoma Christian | 191 | 38-9 | 4 |
| 15 | West Florida | 175 | 33-16 | RV |
| 16 | Young Harris | 148 | 34-12 | 8 |
| 17 | UT Tyler | 142 | 33-7 | 6 |
| 18 | Southern Arkansas | 122 | 29-10 | 19 |
| 19 | Georgian Court | 117 | 38-6 | 22 |
| 20 | Rollins | 111 | 21-4 | 21 |
| 21 | Auburn Montgomery | 80 | 40-7 | 3 |
| 22 | Central Oklahoma | 63 | 36-14 | 14 |
| 23 | Colorado Mesa | 56 | 39-5 | 15 |
| 24 | East Stroudsburg | 46 | 29-16 | |
| 25 | UAH | 27 | 32-14 | 16 |
New to Poll: No. 8 West Chester, No. 15 West Florida, No. 24 East Stroudsburg.
Dropped Out: No. 20 Angelo State, No. 23 Winona State, No. 25 Kutztown.
Receiving Votes: Angelo State (10), Central Missouri (9), Western Washington (9), Northwest Nazarene (3), Texas A&M University-Kingsville (2), Rogers State (1), West Liberty (1).