The University of Texas Tyler is the unanimous No. 1 in the first NFCA Division II Top 25 Coaches Poll of the 2022 season. The Patriots received all 16 first-place votes after starting the season 9-0.
| Rank | School | Points | 2022 Record | Prev. Ranking |
| 1 | UT Tyler (16) | 400 | 9-0 | 1 |
| 2 | Valdosta State | 371 | 6-2 | 7 |
| 3 | North Georgia | 364 | 8-2 | 5 |
| 4 | Concordia Irvine | 363 | 12-0 | 10 |
| 5 | West Texas A&M | 329 | 6-2 | 4 |
| 6 | Minnesota State | 310 | 4-1 | 11 |
| 7 | Grand Valley State | 308 | 0-0 | 6 |
| 8 | Augustana | 292 | 4-3 | 2 |
| 9 | Angelo State | 246 | 10-1 | 18 |
| 10 | Indianapolis | 225 | 3-1 | 12 |
| 11 | Auburn Montgomery | 219 | 5-2 | 14 |
| 12 | Cal State Monterey Bay | 214 | 6-1 | NR |
| 13 | Lincoln Memorial | 196 | 6-2 | 13 |
| 14 | Rogers State | 194 | 10-1 | RV |
| 15 | Oklahoma Christian | 185 | 6-2 | 15 |
| 16 | Central Oklahoma | 138 | 7-2 | 20 |
| 17 | Tampa | 127 | 5-3 | RV |
| 18 | Georgian Court | 124 | 0-0 | 19 |
| 19 | Chico State | 97 | 8-2 | NR |
| 20 | Texas A&M-Kingsville | 89 | 8-1 | RV |
| 21 | West Florida | 80 | 5-3 | 17 |
| 22 | Biola | 74 | 5-4 | 3 |
| 23 | Anderson | 56 | 11-1 | RV |
| 24 | Saint Anselm | 48 | 1-4 | 8 |
| t25 | UAH | 42 | 8-1 | 23 |
| t25 | West Liberty | 42 | 0-0 | 24 |
New to Poll: No. 12 Cal State Monterey Bay, No. 14 Rogers State, No. 17 Tampa, No. 19 Chico State, No. 20 Texas A&M-Kingsville, No. 23 Anderson.
Dropped Out: No. 9 West Chester, No. 16 Southern Arkansas, No. 21 Colorado Mesa, No. 22 Texas A&M University-Commerce, No. 25 Central Missouri.