DePauw, which finished the 2021 season third at the NCAA Championship Finals, has been unanimously voted No. 1 in the NCAA Division III Preseason Coaches Poll. The Tigers are followed by the defending National Champions Virginia Wesleyan at No. 2.
| Rank | Team | Points | 2021 Final Record | 2021 Final Ranking |
| 1 | DePauw (10) | 250 | 40-5 | 3 |
| 2 | Virginia Wesleyan | 240 | 46-6-1 | 1 |
| 3 | Texas Lutheran | 230 | 36-6 | 2 |
| 4 | East Texas Baptist | 220 | 33-7 | 10 |
| 5 | Birmingham-Southern | 210 | 33-8 | 5 |
| 6 | Eastern Connecticut State | 200 | 32-4 | 17 |
| 7 | Tufts | 190 | 21-7 | T8 |
| 8 | Salisbury | 180 | 25-9 | 14 |
| 9 | Rochester | 170 | 35-10 | T8 |
| 10 | The College of New Jersey | 160 | 26-5 | 4 |
| 11 | Milwaukee School of Engineering | 150 | 35-10 | 16 |
| 12 | Wisconsin-Oshkosh | 140 | 29-13 | 6 |
| 13 | Mount St. Joseph | 130 | 33-10 | 12 |
| 14 | Piedmont | 120 | 25-13 | 18 |
| 15 | St. John Fisher | 110 | 31-7 | 11 |
| 16 | Trine | 100 | 30-8 | 21 |
| 17 | Berry | 90 | 25-10 | 15 |
| 18 | Belhaven | 80 | 31-12 | 19 |
| 19 | Christopher Newport | 70 | 28-14 | NR |
| 20 | Linfield | 60 | 38-9 | RV |
| 21 | Millikin | 38 | 31-13 | NR |
| 22 | Brandeis | 26 | 14-3 | RV |
| 23 | Case Western Reserve | 22 | 27-9 | NR |
| 24 | Gettysburg | 17 | 13-5 | RV |
| 25 | Alfred | 12 | 32-11 | 24 |
Others receiving votes: Husson 10, Coe 7, Emory 6, Aurora 5, Benedictine 3, Calvin 3, and Babson 1.