Southern Arkansas has held on to the top spot in this weeks NFCA Division II Top 25 Coaches Poll. SAU opened the season last month 2-0. The Muleriders collected 15 of the 16 first place votes while No. 2 North Georgia collected the other vote.
| Rank | School | Points | 2021 Record | Last Poll |
| 1 | Southern Arkansas (15) | 399 | 2-0 | 1 |
| 2 | North Georgia (1) | 385 | 6-0 | 2 |
| 3 | Augustana | 363 | 0-0 | 3 |
| 4 | UT Tyler | 353 | 2-0 | 4 |
| 5 | Young Harris | 327 | 5-1 | 6 |
| 6 | Saint Leo | 318 | 0-0 | 7 |
| 7 | Texas A&M-Commerce | 311 | 3-1 | 9 |
| 8 | Rollins | 292 | 0-0 | 8 |
| 9 | Angelo State | 271 | 1-1 | 5 |
| 10 | Valdosta State | 233 | 2-1 | 12 |
| 11 | Concordia Irvine | 231 | 0-0 | 11 |
| 12 | Oklahoma Christian | 220 | 2-0 | 13 |
| 13 | Winona State | 188 | 0-0 | 15 |
| 14 | Saint Anselm | 185 | 0-0 | 14 |
| 15 | Lenoir-Rhyne | 176 | 0-0 | 16 |
| 16 | Southern Indiana | 167 | 0-0 | 17 |
| 17 | UAH | 149 | 5-1 | 20 |
| 18 | Rogers State | 134 | 0-0 | 18 |
| 19 | Indianapolis | 115 | 0-0 | 21 |
| 20 | Lincoln Memorial | 106 | 3-0 | 22 |
| 21 | West Chester | 69 | 0-0 | 24 |
| 22 | Tampa | 50 | 0-0 | 24 |
| 23 | Texas A&M-Kingsville | 45 | 2-0 | RV |
| 24 | Grand Valley State | 43 | 0-0 | 25 |
| 25 | Lubbock Christian | 19 | 5-2 | 19 |
Receiving Votes: Minnesota State (17), Metropolitan State University of Denver (8), St. Cloud State (6), Francis Marion (5), Saginaw Valley State (5), Adelphi (4), Central Oklahoma (3), Biola (2), West Liberty (1).